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This document contains a list of frequently asked questions and their answers regarding hormone therapy secondary sexual reassignment for male-to-female transsexuals. More generally, this document contains information about gonadal hormones and anti-hormones, so it can be a helpful reference for the treatment of androgen and estrogen-sensitive conditions—for example, certain cancers of the reproductive organs and breasts. Please send additions, corrections, and suggestions to the Staff. The answers in this document are collected from a variety of sources: medical literature, pharmaceutical company advertizement, verbal advice of medical doctors, second-hand anecdotes, and personal experience. Despite the authoritative tone of this document, it is presented for educational interest only, not direct advice. It contains opinions, sweeping generalizations, and at least one mistake.
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Teenage Hormones & Sexuality | Newport Academy

Transgender hormone therapy of the male-to-female MTF type, also known as transfeminine hormone therapy , is hormone therapy and sex reassignment therapy to change the secondary sexual characteristics of transgender people from masculine or androgynous to feminine. Some intersex people also take this form of therapy, according to their personal needs and preferences. The purpose of the therapy is to cause the development of the secondary sex characteristics of the desired sex , such as breasts and a feminine pattern of hair , fat , and muscle distribution. It cannot undo many of the changes produced by naturally occurring puberty , which may necessitate surgery and other treatments to reverse see below. The medications used for the MTF therapy include estrogens , antiandrogens , progestogens , and gonadotropin-releasing hormone modulators GnRH modulators. While the therapy cannot undo the effects of a person's first puberty , developing secondary sex characteristics associated with one's gender has been shown to relieve some or all of the distress and discomfort associated with gender dysphoria , and can help the person to "pass" or be seen as their gender. The goal of the therapy is to provide patients with a more satisfying body that is more congruent with their gender identity.
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Transgender women on hormone therapy may be at a higher risk for cardiovascular problems, such as stroke, blood clots and heart attack, researchers reported Monday. The study was done by reviewing eight years of medical records of nearly 5, transgender patients in the Kaiser Health system, and looked at patients over the age of 18 who took hormones for gender transition. Over 97, cisgender patients — people whose sex assigned at birth matches their gender identity — with similar age and health characteristics were studied for comparison. The study found that transgender women, who are assigned the male sex at birth, were twice as likely as cisgender men or women to have the blood clot condition venous thromboembolism. Transgender women on hormone therapy were also found to be 80 to 90 percent more likely to have stroke or a heart attack than cisgender women.
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